AustralieFrV1, Main, Exploration, bibRecord, 00CC05

Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia

Identifieur interne : 00CC05 ( Main/Exploration ); précédent : 00CC04; suivant : 00CC06

Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia

Auteurs : J. R. Passweg [États-Unis] ; P. Tiberghien [France] ; J.-Y. Cahn [France] ; M. R. Vowels [Australie] ; B. M. Camitta [États-Unis] ; R. P. Gale [États-Unis] ; R. H. Herzig [États-Unis] ; D. Hoelzer [Allemagne] ; M. M. Horowitz [États-Unis] ; N. Ifrah [France] ; J. P. Klein [États-Unis] ; D. I. Marks [États-Unis] ; N. K. C. Ramsay [États-Unis] ; P. A. Rowlings [États-Unis] ; D. J. Weisdorf [États-Unis] ; M.-J. Zhang [États-Unis] ; A. J. Barrett [États-Unis]

Source :

Bone marrow transplantation : (Basingstoke) [ 0268-3369 ] ; 1998.

RBID : Pascal:98-0124769

Descripteurs français

Pascal (Inist)
- Leucémie lymphoblastique, Réaction greffon leucémie, Réponse immune, Lymphocyte T, Lymphocyte B, Immunité cellulaire, Immunité humorale, Homme, Maladie greffon hôte, Récidive, Facteur risque, Aigu.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Acute, Acute lymphocytic leukemia, B-Lymphocyte, Cellular immunity, Graft versus host reaction, Graft versus leukemia reaction, Human, Humoral immunity, Immune response, Relapse, Risk factor, T-Lymphocyte.

Abstract

T and B lineage ALL cells express different levels of HLA-class II antigens, which may serve as targets for graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). The object of this study was to determine whether GVL effects after HLA-identical sibling bone marrow transplantation differed in T and B lineage ALL. We studied 1132 patients with ALL of T lineage (n = 416) or of B lineage (cALLa⁺) (n = 716) transplanted in first (n = 605) or second (n = 527) remission with bone marrow from an HLA-identical sibling donor, between 1982 and 1992, and reported to the IBMTR by 165 teams. Cox proportional hazards regression models were used to determine the relative risk (RR) of relapse in patients with acute (grades II-IV) or chronic GVHD vs patients without GVHD. Acute and chronic GVHD were considered as time-dependent covariates. Patients transplanted in first and second remission were analyzed separately. GVHD decreased relapse risks to a similar extent in T and B lineage ALL. For first remission transplants, relative risks of relapse for patients with vs those without GVHD was 0.34 for T lineage ALL and 0.44 for B lineage ALL. Corresponding relative risks in second remission transplants were 0.54 and 0.61. This study confirms earlier findings of an antileukemia effect of GVHD in ALL. This effect was similar in T lineage and B lineage ALL, despite probable differences in HLA-class II antigen expression.

Affiliations:

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Le document en format XML

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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Milwaukee, WI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weisdorf, D J" sort="Weisdorf, D J" uniqKey="Weisdorf D" first="D. J." last="Weisdorf">D. J. Weisdorf</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Bone Marrow Transplant Program, University of Minnesota Hospital and Clinics</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, M J" sort="Zhang, M J" uniqKey="Zhang M" first="M.-J." last="Zhang">M.-J. Zhang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>International Bone Marrow Transplant Registry (IBMTR), Health Policy Institute, Medical College of Wisconsin</s1>
<s2>Milwaukee, WI</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Milwaukee, WI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barrett, A J" sort="Barrett, A J" uniqKey="Barrett A" first="A. J." last="Barrett">A. J. Barrett</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>National Heart, Lung and Blood Institute, National Institutes of Health</s1>
<s2>Bethesda, MD</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, MD</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
<imprint><date when="1998">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Acute lymphocytic leukemia</term>
<term>B-Lymphocyte</term>
<term>Cellular immunity</term>
<term>Graft versus host reaction</term>
<term>Graft versus leukemia reaction</term>
<term>Human</term>
<term>Humoral immunity</term>
<term>Immune response</term>
<term>Relapse</term>
<term>Risk factor</term>
<term>T-Lymphocyte</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Leucémie lymphoblastique</term>
<term>Réaction greffon leucémie</term>
<term>Réponse immune</term>
<term>Lymphocyte T</term>
<term>Lymphocyte B</term>
<term>Immunité cellulaire</term>
<term>Immunité humorale</term>
<term>Homme</term>
<term>Maladie greffon hôte</term>
<term>Récidive</term>
<term>Facteur risque</term>
<term>Aigu</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">T and B lineage ALL cells express different levels of HLA-class II antigens, which may serve as targets for graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). The object of this study was to determine whether GVL effects after HLA-identical sibling bone marrow transplantation differed in T and B lineage ALL. We studied 1132 patients with ALL of T lineage (n = 416) or of B lineage (cALLa<sup>+</sup>
) (n = 716) transplanted in first (n = 605) or second (n = 527) remission with bone marrow from an HLA-identical sibling donor, between 1982 and 1992, and reported to the IBMTR by 165 teams. Cox proportional hazards regression models were used to determine the relative risk (RR) of relapse in patients with acute (grades II-IV) or chronic GVHD vs patients without GVHD. Acute and chronic GVHD were considered as time-dependent covariates. Patients transplanted in first and second remission were analyzed separately. GVHD decreased relapse risks to a similar extent in T and B lineage ALL. For first remission transplants, relative risks of relapse for patients with vs those without GVHD was 0.34 for T lineage ALL and 0.44 for B lineage ALL. Corresponding relative risks in second remission transplants were 0.54 and 0.61. This study confirms earlier findings of an antileukemia effect of GVHD in ALL. This effect was similar in T lineage and B lineage ALL, despite probable differences in HLA-class II antigen expression.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Bourgogne-Franche-Comté</li>
<li>District de Darmstadt</li>
<li>Franche-Comté</li>
<li>Hesse (Land)</li>
<li>Pays de la Loire</li>
</region>
<settlement><li>Angers</li>
<li>Besançon</li>
<li>Francfort-sur-le-Main</li>
</settlement>
<orgName><li>Université Johann Wolfgang Goethe de Francfort-sur-le-Main</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Passweg, J R" sort="Passweg, J R" uniqKey="Passweg J" first="J. R." last="Passweg">J. R. Passweg</name>
</noRegion>
<name sortKey="Barrett, A J" sort="Barrett, A J" uniqKey="Barrett A" first="A. J." last="Barrett">A. J. Barrett</name>
<name sortKey="Camitta, B M" sort="Camitta, B M" uniqKey="Camitta B" first="B. M." last="Camitta">B. M. Camitta</name>
<name sortKey="Gale, R P" sort="Gale, R P" uniqKey="Gale R" first="R. P." last="Gale">R. P. Gale</name>
<name sortKey="Herzig, R H" sort="Herzig, R H" uniqKey="Herzig R" first="R. H." last="Herzig">R. H. Herzig</name>
<name sortKey="Horowitz, M M" sort="Horowitz, M M" uniqKey="Horowitz M" first="M. M." last="Horowitz">M. M. Horowitz</name>
<name sortKey="Klein, J P" sort="Klein, J P" uniqKey="Klein J" first="J. P." last="Klein">J. P. Klein</name>
<name sortKey="Marks, D I" sort="Marks, D I" uniqKey="Marks D" first="D. I." last="Marks">D. I. Marks</name>
<name sortKey="Ramsay, N K C" sort="Ramsay, N K C" uniqKey="Ramsay N" first="N. K. C." last="Ramsay">N. K. C. Ramsay</name>
<name sortKey="Rowlings, P A" sort="Rowlings, P A" uniqKey="Rowlings P" first="P. A." last="Rowlings">P. A. Rowlings</name>
<name sortKey="Weisdorf, D J" sort="Weisdorf, D J" uniqKey="Weisdorf D" first="D. J." last="Weisdorf">D. J. Weisdorf</name>
<name sortKey="Zhang, M J" sort="Zhang, M J" uniqKey="Zhang M" first="M.-J." last="Zhang">M.-J. Zhang</name>
</country>
<country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Tiberghien, P" sort="Tiberghien, P" uniqKey="Tiberghien P" first="P." last="Tiberghien">P. Tiberghien</name>
</region>
<name sortKey="Cahn, J Y" sort="Cahn, J Y" uniqKey="Cahn J" first="J.-Y." last="Cahn">J.-Y. Cahn</name>
<name sortKey="Ifrah, N" sort="Ifrah, N" uniqKey="Ifrah N" first="N." last="Ifrah">N. Ifrah</name>
</country>
<country name="Australie"><noRegion><name sortKey="Vowels, M R" sort="Vowels, M R" uniqKey="Vowels M" first="M. R." last="Vowels">M. R. Vowels</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Hoelzer, D" sort="Hoelzer, D" uniqKey="Hoelzer D" first="D." last="Hoelzer">D. Hoelzer</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia

Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia

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